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Invitrogen
PrP Polyclonal Antibody
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Product Details
PA5-111160
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human PrP. Recombinant protein control fragment (Product #RP-99454).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SDYEDRYYRE NMHRYPNQVY YRPMDEYSNQ NNFVHDCVNI TIKQHTVTTT TKGENFTETD VKMMERVVEQ MCITQYE
Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 91%.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alternative prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; Major prion protein; MGC26679; prion protein; prion-related protein; PRNP; PrP; PrP27-30; PrP33-35C; TSE; unnamed protein product
Gene Aliases: ALTPRP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PRNP; PRP; PrP27-30; PrP33-35C; PrPc
UniProt ID: (Human) P04156
Entrez Gene ID: (Human) 5621
beta-amyloid binding
protease binding
copper ion binding
protein binding
lamin binding
glycosaminoglycan binding
microtubule binding
tubulin binding
aspartic-type endopeptidase inhibitor activity
type 5 metabotropic glutamate receptor binding
type 8 metabotropic glutamate receptor binding
signaling receptor activity
identical protein binding
ATP-dependent protein binding
ion channel binding
macromolecular complex binding
metal ion binding
chaperone binding
binding, bridging
molecular function activator activity
molecular condensate scaffold activity
cupric ion binding
cuprous ion binding
negative regulation of transcription from RNA polymerase II promoter
cellular copper ion homeostasis
response to oxidative stress
learning or memory
long-term memory
negative regulation of protein processing
protein destabilization
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
negative regulation of interleukin-2 production
regulation of protein localization
intracellular signal transduction
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of activated T cell proliferation
response to cadmium ion
response to copper ion
positive regulation of calcium-mediated signaling
negative regulation of T cell receptor signaling pathway
protein homooligomerization
regulation of cell cycle
negative regulation of calcineurin-NFAT signaling cascade
cellular response to copper ion
cellular response to xenobiotic stimulus
positive regulation of protein targeting to membrane
dendritic spine maintenance
negative regulation of long-term synaptic potentiation
regulation of glutamate receptor signaling pathway
positive regulation of glutamate receptor signaling pathway
regulation of potassium ion transmembrane transport
negative regulation of beta-amyloid formation
negative regulation of dendritic spine maintenance
negative regulation of amyloid precursor protein catabolic process
positive regulation of protein localization to plasma membrane
response to amyloid-beta
cellular response to beta-amyloid
regulation of calcium ion import across plasma membrane
neuron projection maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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