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Invitrogen
FNIP2 Polyclonal Antibody
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Product Details
PA5-111162
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human FNIP2. Recombinant protein control fragment (Product #RP-100176).
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDQQAVCELL KVEMPTRLPD RSVAWPCPDR HLREKPSLEK VTFQIGSFAS PESDFESRMK KMEERVKACG PSLEASEAAD VAQDPQVSRS P
Highest antigen sequence indentity to the following orthologs: Rat - 55%, Mouse - 52%.
Target Information
FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FNIP1-like protein; Folliculin-interacting protein 2; O6-methylguanine-induced apoptosis 1 protein
Gene Aliases: FNIP2; FNIPL; KIAA1450; MAPO1
UniProt ID: (Human) Q9P278
Entrez Gene ID: (Human) 57600
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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