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Invitrogen
Nodal Polyclonal Antibody
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Product Details
PA5-111214
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Nodal. Recombinant protein control fragment (Product #RP-91947).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PTEGSLAIEI FHQPKPDTEQ ASDSCLERFQ MDLFTVTLSQ VTFSLGSMVL EVTRPLSKWL KHPGALEKQM SRV
Highest antigen sequence indentity to the following orthologs: Mouse - 64%, Rat - 64%.
Target Information
NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC138230; Nodal homolog
Gene Aliases: HTX5; NODAL
UniProt ID: (Human) Q96S42
Entrez Gene ID: (Human) 4838
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
gastrulation with mouth forming second
formation of primary germ layer
mesoderm formation
trophectodermal cell differentiation
trophectodermal cellular morphogenesis
neural fold formation
liver development
placenta development
embryonic placenta development
maternal placenta development
vasculature development
heart looping
inhibition of neuroepithelial cell differentiation
determination of left/right asymmetry in lateral mesoderm
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
gastrulation
nervous system development
brain development
endoderm development
heart development
female pregnancy
cell proliferation
positive regulation of cell proliferation
embryonic pattern specification
anterior/posterior axis specification
anterior/posterior pattern specification
regulation of signal transduction
polarity specification of proximal/distal axis
regulation of gastrulation
positive regulation of vascular endothelial growth factor production
negative regulation of cell development
cell migration
stem cell population maintenance
positive regulation of cell-cell adhesion
cell differentiation
lung development
floor plate morphogenesis
somatic stem cell population maintenance
embryonic heart tube development
endodermal cell differentiation
nodal signaling pathway
cell migration involved in gastrulation
cell fate commitment
negative regulation of cell differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
axial mesodermal cell fate specification
mesendoderm development
digestive tract morphogenesis
anatomical structure formation involved in morphogenesis
embryonic cranial skeleton morphogenesis
tissue morphogenesis
formation of anatomical boundary
positive regulation of epithelial cell proliferation
digestive system development
embryonic process involved in female pregnancy
maternal process involved in parturition
positive regulation of SMAD protein import into nucleus
left lung morphogenesis
negative regulation of androgen receptor signaling pathway
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
positive regulation of ERK1 and ERK2 cascade
primitive streak formation
apoptotic signaling pathway
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
regulation of stem cell population maintenance
negative regulation of reproductive process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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