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Invitrogen
Bcl-3 Polyclonal Antibody
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Product Details
PA5-111255
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Bcl-3. Recombinant protein control fragment (Product #RP-106148).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AQMYSGSSAL HSASGRGLLP LVRTLVRSGA DSSLKNCHND TPLMVARSRR VIDILRGKAT RPASTSQPDP SPDRSANTSP ESSSRLSSN
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 91%.
Target Information
B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B cell CLL/lymphoma 3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3 protein; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; lymphoma 3-encoded protein (bcl-3); Proto-oncogene BCL3; unnamed protein product
Gene Aliases: BCL3; BCL4; D19S37
UniProt ID: (Human) P20749
Entrez Gene ID: (Human) 602
negative regulation of cytokine production
follicular dendritic cell differentiation
marginal zone B cell differentiation
humoral immune response mediated by circulating immunoglobulin
germinal center formation
protein import into nucleus
apoptotic process
response to stress
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
response to virus
response to UV-C
positive regulation of gene expression
antimicrobial humoral response
extracellular matrix organization
DNA damage response, signal transduction by p53 class mediator
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
T-helper 1 type immune response
defense response to bacterium
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
defense response to protozoan
regulation of apoptotic process
negative regulation of apoptotic process
T-helper 2 cell differentiation
positive regulation of translation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
spleen development
regulation of DNA binding
response to other organism
T cell apoptotic process
negative regulation of T cell apoptotic process
regulation of NIK/NF-kappaB signaling
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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