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Invitrogen
Apoptosis-Enhancing Nuclease Polyclonal Antibody
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Product Details
PA5-111279
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Apoptosis-Enhancing Nuclease. Recombinant protein control fragment (Product #RP-98170).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLTIPNAKDV LRKRHKRRSR QHQRFMARKA LLQEQGLLSM PPEPGSSPLP TPFGAATATE AASSGKQCLR AGSGSAP
Highest antigen sequence indentity to the following orthologs: Rat - 62%, Mouse - 62%.
Target Information
Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis-enhancing nuclease; interferon stimulated exonuclease gene 20kDa-like 1; Interferon-stimulated 20 kDa exonuclease-like 1
Gene Aliases: AEN; ISG20L1; pp12744; SBBI58
UniProt ID: (Human) Q8WTP8
Entrez Gene ID: (Human) 64782
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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