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Invitrogen
Kir6.2 (KCNJ11) Polyclonal Antibody
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Product Details
PA5-111283
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Kir6.2 (KCNJ11). Recombinant protein control fragment (Product #RP-100884).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TVKVPTPLCT ARQLDEDHSL LEALTLASAR GPLRKRSVPM AKAKPKFSIS PDSLS
Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 89%.
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; beta-cell inward rectifier subunit; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; IRK11; KATP; KATP channel; MGC133230; potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly-rectifying channel, subfamily J, member 11
Gene Aliases: BIR; HHF2; IKATP; KCNJ11; KIR6.2; MODY13; PHHI; TNDM3
UniProt ID: (Human) Q14654
Entrez Gene ID: (Human) 3767
response to ischemia
glucose metabolic process
potassium ion import
response to estradiol
response to ATP
response to testosterone
regulation of membrane potential
response to drug
negative regulation of insulin secretion
regulation of insulin secretion
neurological system process
transmembrane transport
cellular response to nicotine
cellular response to glucose stimulus
cellular response to tumor necrosis factor
potassium ion transmembrane transport
regulation of cardiac conduction
positive regulation of cation channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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