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Invitrogen
RUNX1T1 Polyclonal Antibody
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Product Details
PA5-111303
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human RUNX1T1. Recombinant protein control fragment (Product #RP-104886).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KGGGSSSSHS RQQSPVNPDP VALDAHREFL HRPASGYVPE EIWKKAE
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 98%.
Target Information
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acute myelogenous leukemia 1 translocation 1, cyclin-D related; CBFA2T1 isoform r1t1-11a61; CBFA2T1 isoform r1t1-11a62; CBFA2T1 isoform r1t1-11a63; CBFA2T1 isoform r1t1-11a64; CBFA2T1 isoform r1t1-11a65; CBFA2T1 isoform r1t1-7a47; CBFA2T1 isoform r1t1-7a48; CBFA2T1 isoform r1t1-7a49; CBFA2T1 isoform r1t1-7a50; CBFA2T1 isoform r1t1-7a51; CBFA2T1 isoform r1t1-7a52; CBFA2T1 isoform r1t1-7d53; CBFA2T1 isoform r1t1-7d54; CBFA2T1 isoform r1t1-7d55; CBFA2T1 isoform r1t1-7d56; CBFA2T1 isoform r1t1-8a57; CBFA2T1 isoform r1t1-8a58; CBFA2T1 isoform r1t1-8a59; CBFA2T1 isoform r1t1-8a60; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; MGC2796; MTG8b; myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG8; runt related transcription factor 1; translocated to, 1 (cyclin D related); runt-related transcription factor 1; translocated to, 1 (cyclin D-related); Zinc finger MYND domain-containing protein 2
Gene Aliases: AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; RUNX1T1; ZMYND2
UniProt ID: (Human) Q06455
Entrez Gene ID: (Human) 862
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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