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Invitrogen
Apolipoprotein C1 Polyclonal Antibody
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Product Details
PA5-111339
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Apolipoprotein C1. Recombinant protein control fragment (Product #RP-101269).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PDVSSALDKL KEFGNTLEDK ARELISRIKQ SELSAKMREW FSETFQKVKE
Highest antigen sequence indentity to the following orthologs: Mouse - 65%, Rat - 65%.
Target Information
Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues. The human apoC-III gene maps to chromosome 11q23 and encodes a protein that may delay catabolism of triglyceride-rich particles by inhibiting lipoprotein lipase and hepatic lipase. The human apoC-IV gene maps to chromosome 19q13.2 and encodes a 127 amino acid protein that is primarily expressed in the liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-CI; APOC1; Apolipoprotein C-I; Apolipoprotein C1; apolipoprotein CI; unnamed protein product
Gene Aliases: Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1; APOC1B
UniProt ID: (Human) P02654
Entrez Gene ID: (Human) 341
lipid metabolic process
triglyceride metabolic process
lipid transport
cholesterol metabolic process
negative regulation of triglyceride catabolic process
negative regulation of phosphatidylcholine catabolic process
negative regulation of very-low-density lipoprotein particle clearance
regulation of cholesterol transport
negative regulation of cholesterol transport
cholesterol efflux
phospholipid efflux
plasma lipoprotein particle remodeling
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
chylomicron remnant clearance
very-low-density lipoprotein particle clearance
lipoprotein metabolic process
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
triglyceride homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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