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Invitrogen
TRPM7 Polyclonal Antibody
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Product Details
PA5-111348
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TRPM7. Recombinant protein control fragment (Product #RP-106377).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SQPSCKSHLE TGTKDQETVC SKATEGDNTE FGAFVGHRDS MDLQRFKETS NKIKILSNNN TSENTLKRVS SLAGFTDCHR TSIPVHSKQA EKISRRPSTE DTHEVDSKAA LIPDWLQDRP SNREMPSEEG TLNGLTSPFK PAM
Highest antigen sequence indentity to the following orthologs: Mouse - 73%, Rat - 70%.
Target Information
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ChaK1; melanoma alpha-kinase; Channel kinase 1; Channel-kinase 1; FLJ20117; Long transient receptor potential channel 7; LTRPC ion channel family member 7; LTrpC-7; member of LTRPC ion channel family; tr; Transient receptor potential cation channel subfamily M member 7; transient receptor potential-phospholipase C-interacting kinase; TRMP7; TRP PLIK; unnamed protein product
Gene Aliases: ALSPDC; CHAK; CHAK1; LTrpC-7; LTRPC7; TRP-PLIK; TRPM7
UniProt ID: (Human) Q96QT4
Entrez Gene ID: (Human) 54822
nucleotide binding
actin binding
protein kinase activity
protein serine/threonine kinase activity
ion channel activity
cation channel activity
calcium channel activity
zinc ion transmembrane transporter activity
protein binding
ATP binding
magnesium ion transmembrane transporter activity
kinase activity
transferase activity
myosin binding
metal ion binding
protein serine kinase activity
protein phosphorylation
ion transport
calcium ion transport
zinc II ion transport
magnesium ion homeostasis
cellular magnesium ion homeostasis
programmed cell death
magnesium ion transport
calcium-dependent cell-matrix adhesion
actomyosin structure organization
ion transmembrane transport
protein autophosphorylation
protein tetramerization
protein homotetramerization
transmembrane transport
necroptotic process
calcium ion transmembrane transport
zinc II ion transmembrane transport
cation transmembrane transport
magnesium ion transmembrane transport
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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