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Invitrogen
RAD50 Polyclonal Antibody
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Product Details
PA5-111350
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human RAD50. Recombinant protein control fragment (Product #RP-103119).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELREPQFRDA EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM EEINKIIRDL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVV
Highest antigen sequence indentity to the following orthologs: Rat - 99%, Mouse - 100%.
Target Information
Rad50-13B3 recognizes human Rad50, a 153a protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, Rad50 and Mre11 redistribute and are co-localized within the nucleus of damaged cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein RAD50; hRAD50; hsRAD50; RAD50 2; RAD50 homolog, double strand break repair protein; RAD50 PEN; RAD50-2; RAD50-3
Gene Aliases: hRad50; NBSLD; RAD50; RAD502
UniProt ID: (Human) Q92878
Entrez Gene ID: (Human) 10111
single-stranded DNA endodeoxyribonuclease activity
DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
adenylate kinase activity
protein binding
ATP binding
3'-5' exonuclease activity
protein binding, bridging
single-stranded telomeric DNA binding
metal ion binding
G-quadruplex DNA binding
regulation of mitotic recombination
telomere maintenance via recombination
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
reciprocal meiotic recombination
viral process
telomeric 3' overhang formation
positive regulation of protein autophosphorylation
positive regulation of telomere maintenance
DNA duplex unwinding
positive regulation of kinase activity
nucleotide phosphorylation
chromosome organization involved in meiotic cell cycle
nucleic acid phosphodiester bond hydrolysis
regulation of signal transduction by p53 class mediator
negative regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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