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Invitrogen
MD-2 Polyclonal Antibody
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Product Details
PA5-111367
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human MD-2. Recombinant protein control fragment (Product #RP-106439).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RKEVICRGSD DDYSFCRALK GETVNTTISF SFKGIKFSKG KYKCVVEAIS GSPEEMLFCL EFVILHQPNS N
Highest antigen sequence indentity to the following orthologs: Mouse - 69%, Rat - 26%.
Target Information
MD-2 is a gene that encodes a protein involved in the recognition of bacterial lipopolysaccharides (LPS) by the immune system. It is located on chromosome 8 and is part of a larger family of genes that encode for similar proteins. The MD-2 protein forms a complex with Toll-like receptor 4 (TLR4) to recognize and respond to LPS, triggering an immune response. Mutations or variations in the MD-2 gene have been associated with various diseases and conditions, including sepsis and inflammatory disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine; ESOP-1; Ly-96; Lymphocyte antigen 96; MD-2; myeloid differentiation protein-2; Protein MD-2
Gene Aliases: ESOP-1; ESOP1; ly-96; LY96; MD-2; MD2
UniProt ID: (Human) Q9Y6Y9
Entrez Gene ID: (Human) 23643
pattern recognition receptor signaling pathway
toll-like receptor signaling pathway
immune system process
inflammatory response
cellular defense response
cell surface receptor signaling pathway
lipopolysaccharide-mediated signaling pathway
positive regulation of lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
detection of lipopolysaccharide
positive regulation of tumor necrosis factor production
toll-like receptor 4 signaling pathway
innate immune response
cellular response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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