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Invitrogen
HBEGF Polyclonal Antibody
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Product Details
PA5-111370
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human HBEGF. Recombinant protein control fragment (Product #RP-101213).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IHGECKYVKE LRAPSCICHP GYHGERCHGL SLPVENRLYT YDHTTI
Highest antigen sequence indentity to the following orthologs: Mouse - 76%, Rat - 80%.
Target Information
HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); hb egf; heparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; Proheparin-binding EGF-like growth factor
Gene Aliases: DTR; DTS; DTSF; HBEGF; HEGFL
UniProt ID: (Human) Q99075
Entrez Gene ID: (Human) 1839
MAPK cascade
signal transduction
epidermal growth factor receptor signaling pathway
muscle organ development
regulation of heart contraction
positive regulation of cell proliferation
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
positive regulation of cell migration
wound healing, spreading of epidermal cells
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
negative regulation of elastin biosynthetic process
positive regulation of keratinocyte migration
positive regulation of protein kinase B signaling
cell chemotaxis
positive regulation of wound healing
regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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