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Invitrogen
PLA2G4A Polyclonal Antibody
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Product Details
PA5-111389
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human PLA2G4A. Recombinant protein control fragment (Product #RP-103178).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PRETEEEKEI ADFDIFDDPE SPFSTFNFQY PNQAFKRLHD LMHFNTLNNI DVIKEAMVES IEYRRQNPSR CSVSLSNVEA RRFFNKEFLS K
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 93%.
Target Information
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium-dependent phospholipid-binding protein; cPLA2; cytosolic group IVA; Cytosolic phospholipase A2; group IVA; lysophospholipase; MGC126350; phosphatidylcholine 2-acylhydrolase; phospholipase A2; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); unnamed protein product
Gene Aliases: CPLA2; cPLA2-alpha; GURDP; PLA2G4; PLA2G4A
UniProt ID: (Human) P47712
Entrez Gene ID: (Human) 5321
phospholipase activity
lysophospholipase activity
phospholipase A2 activity
calcium ion binding
calcium-dependent phospholipid binding
lipid binding
O-acyltransferase activity
phosphatidylinositol-5-phosphate binding
hydrolase activity
phosphatidylinositol-3-phosphate binding
metal ion binding
calcium-dependent phospholipase A2 activity
calcium-independent phospholipase A2 activity
carboxylic ester hydrolase activity
phosphatidylinositol-4-phosphate binding
ceramide 1-phosphate binding
prostaglandin biosynthetic process
positive regulation of T-helper 1 type immune response
glycerol metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
monoacylglycerol biosynthetic process
glycerophospholipid metabolic process
platelet activating factor biosynthetic process
icosanoid metabolic process
prostaglandin metabolic process
phospholipid catabolic process
positive regulation of platelet activation
lipid catabolic process
arachidonic acid metabolic process
leukotriene biosynthetic process
positive regulation of prostaglandin secretion
phosphatidylglycerol catabolic process
phosphatidylcholine catabolic process
phosphatidylcholine acyl-chain remodeling
regulation of cell proliferation
positive regulation of macrophage activation
icosanoid biosynthetic process
glycerophospholipid catabolic process
arachidonic acid secretion
establishment of localization in cell
cellular response to antibiotic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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