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Invitrogen
Uromodulin Polyclonal Antibody
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FIGURE: 1 / 6
Uromodulin Antibody (PA5-111399) in IHC (P)
Immunohistochemistry analysis of Uromodulin in human cerebral cortex, kidney, placenta and testis. Samples were incubated with Uromodulin polyclonal antibody (Product # PA5-111399). Shows similar protein distribution across tissues to independent Uromodulin antibody (Product # PA5-53658) (B).
Product Details
PA5-111399
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Uromodulin. Recombinant protein control fragment (Product #RP-98765).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLGFDKVFMY LSDSRCSGFN DRDNRDWVSV VTPARDGPCG TVLTRNETHA TYSNTLYLAD EIIIRDLNIK INFACSYP
Highest antigen sequence indentity to the following orthologs: Rat - 81%, Mouse - 74%.
Target Information
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Tamm-Horsfall urinary glycoprotein; THP; unnamed protein product; Uromodulin; uromodulin precursor; uromucoid; uromucoid uromucoid
Gene Aliases: ADMCKD2; ADTKD1; FJHN; HNFJ; HNFJ1; MCKD2; THGP; THP; UMOD
UniProt ID: (Human) P07911
Entrez Gene ID: (Human) 7369
kidney development
organ or tissue specific immune response
immune system process
renal water homeostasis
glomerular filtration
lipid metabolic process
cellular calcium ion homeostasis
cellular sodium ion homeostasis
autophagy
apoptotic process
inflammatory response
cellular defense response
response to unfolded protein
endoplasmic reticulum organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
regulation of blood pressure
negative regulation of cell proliferation
RNA splicing
response to xenobiotic stimulus
response to water deprivation
gene expression
urate transport
cellular phosphate ion homeostasis
cellular chloride ion homeostasis
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
cellular response to stress
multicellular organismal response to stress
cellular response to unfolded protein
response to endoplasmic reticulum stress
regulation of urine volume
ERAD pathway
protein transport into plasma membrane raft
innate immune response
citric acid secretion
multicellular organismal homeostasis
chemical homeostasis
ion homeostasis
defense response to Gram-negative bacterium
multicellular organismal water homeostasis
regulation of protein transport
phosphate ion homeostasis
chloride ion homeostasis
calcium ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
micturition
renal sodium ion absorption
urea transmembrane transport
collecting duct development
juxtaglomerular apparatus development
loop of Henle development
metanephric ascending thin limb development
metanephric distal convoluted tubule development
metanephric thick ascending limb development
protein localization to vacuole
apoptotic signaling pathway
connective tissue replacement
urate salt excretion
antibacterial innate immune response
neutrophil migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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