Search
Invitrogen
SMAD6 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-111539
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human SMAD6. Recombinant protein control fragment (Product #RP-107111).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PRPMSEPGAG AGSSLLDVAE PGGPGWLPES DCETVTCCLF
Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: MAD homolog 6; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; SMAD; SMAD 6; SMAD family member; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6
Gene Aliases: AOVD2; HsT17432; MADH6; MADH7; SMAD6
UniProt ID: (Human) O43541
Entrez Gene ID: (Human) 4091
transcription regulatory region sequence-specific DNA binding
chromatin binding
protein binding
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
identical protein binding
metal ion binding
co-SMAD binding
I-SMAD binding
R-SMAD binding
activin receptor binding
type I activin receptor binding
protein sequestering activity
transcription regulator inhibitor activity
ureteric bud development
outflow tract septum morphogenesis
heart valve development
aortic valve morphogenesis
mitral valve morphogenesis
pulmonary valve morphogenesis
ventricular septum development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
immune response
zygotic specification of dorsal/ventral axis
negative regulation of cell proliferation
anatomical structure morphogenesis
cell differentiation
negative regulation of ossification
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
cell-substrate adhesion
response to lipopolysaccharide
negative regulation of activin receptor signaling pathway
response to laminar fluid shear stress
aorta development
negative regulation of apoptotic process
response to estrogen
fat cell differentiation
negative regulation of cell differentiation
negative regulation of osteoblast differentiation
negative regulation of SMAD protein import into nucleus
SMAD protein signal transduction
coronary vasculature development
cellular response to growth factor stimulus
transforming growth factor beta receptor superfamily signaling pathway
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support