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Invitrogen
RANGAP1 Polyclonal Antibody
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Product Details
PA5-111541
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human RANGAP1. Recombinant protein control fragment (Product #RP-105220).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NFGDCLVRSK GAVAIADAIR GGLPKLKELN LSFCEIKRDA ALAVAEAMAD KAELEKLDLN GNTLGEEGCE QLQEVLEGFN MAKVLASLSD D
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 93%.
Target Information
Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC20266; Ran GTPase-activating protein 1; RANGAP1; segregation distorter homolog; unnamed protein product
Gene Aliases: Fug1; KIAA1835; RANGAP; RANGAP1; SD
UniProt ID: (Human) P46060
Entrez Gene ID: (Human) 5905
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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