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Invitrogen
WNT10B Polyclonal Antibody
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Product Details
PA5-111550
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human WNT10B. Recombinant protein control fragment (Product #RP-107174).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SCQFKTCWRA APEFRAVGAA LRERLGRAIF IDTHNRNSGA FQPRLRPRRL SGELVYFEKS
Highest antigen sequence indentity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein Wnt-10b; Protein Wnt-12; unnamed protein product; wingless-type MMTV integration site family, member 10B; WNT-10B protein; WNT10B
Gene Aliases: SHFM6; STHAG8; WNT-12; WNT10B; WNT12
UniProt ID: (Human) O00744
Entrez Gene ID: (Human) 7480
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
chondrocyte differentiation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
lipid metabolic process
smoothened signaling pathway
cell proliferation
positive regulation of G2/M transition of mitotic cell cycle
myoblast differentiation involved in skeletal muscle regeneration
Wnt signaling pathway
neuron differentiation
T cell differentiation
positive regulation of bone mineralization
epithelial cell differentiation
positive regulation of epithelial cell differentiation
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
skeletal muscle tissue regeneration
cell fate commitment
fat cell differentiation
positive regulation of T cell differentiation
regulation of fat cell differentiation
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription from RNA polymerase II promoter
animal organ development
myoblast development
regulation of skeletal muscle tissue development
skeletal muscle fiber development
negative regulation of epithelial cell proliferation
protein stabilization
sensory perception of taste
regulation of protein metabolic process
regulation of cell cycle
positive regulation of anagen
canonical Wnt signaling pathway
bone trabecula formation
fungiform papilla development
cellular response to retinoic acid
cellular response to cAMP
cellular response to parathyroid hormone stimulus
hematopoietic stem cell proliferation
positive regulation of canonical Wnt signaling pathway
negative regulation of cold-induced thermogenesis
positive regulation of hematopoietic stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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