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Invitrogen
IDE Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-111566
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human IDE. Recombinant protein control fragment (Product #RP-103514).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EKNVMNDAWR LFQLEKATGN PKHPFSKFGT GNKYTLETRP NQEGIDVRQE LLKFHSAYYS SNLMAVCVLG RESLDDLTNL VVKLFSEVEN KNVPLPEFPE HP
Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 97%.
Target Information
This gene may belong to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abeta-degrading protease; FLJ35968; Insulin degrading enzyme; insulin protease; insulinase; unnamed protein product
Gene Aliases: INSULYSIN
UniProt ID: (Human) P14735
Entrez Gene ID: (Human) 3416
beta-amyloid binding
endopeptidase activity
metalloendopeptidase activity
protein binding
ATP binding
zinc ion binding
ATPase activity
peptide hormone binding
beta-endorphin binding
peptide binding
identical protein binding
protein homodimerization activity
insulin binding
macromolecular complex binding
metal ion binding
proteolysis
insulin receptor signaling pathway
bradykinin catabolic process
ubiquitin homeostasis
antigen processing and presentation of endogenous peptide antigen via MHC class I
protein catabolic process
positive regulation of protein binding
hormone catabolic process
peptide catabolic process
positive regulation of protein catabolic process
negative regulation of proteolysis
beta-amyloid metabolic process
beta-amyloid clearance
amyloid-beta clearance by cellular catabolic process
insulin metabolic process
insulin catabolic process
regulation of aerobic respiration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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