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Invitrogen
DUSP3 Polyclonal Antibody
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Product Details
PA5-111569
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human DUSP3. Recombinant protein control fragment (Product #RP-107263).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LVIAYLMMRQ KMDVKSALSI VRQNREIGPN DGFLAQLCQL NDRLAKEGKL KP
Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 94%.
Target Information
Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules, such as the MAP kinase family. Recently, increasing attention has been focused on the growing family of PTPs. Like PTKs, PTPs have been implicated in cell signaling, cell growth and proliferation, and oncogenic transformation. Moreover, some PTPs can be involved in cell cycle regulation and embryogenesis. Dual specificity phosphatases (DSPs) are an emerging subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which appears to be selective for dephosphorylating the critical phosphothreonine and phosphotyrosine residues. The prototypical DSP is the VH1 gene in vaccinia virus expressed in late-stage viral infection. A shallow active site pocket in VHR allows for the hydrolysis of phosphorylated serine, threonine, or tyrosine protein residues, whereas the deeper active site of protein tyrosine phosphatases (PTPs) restricts substrate specificity to only phosphotyrosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUSP 3; DUSP-3; serine/threonine specific protein phosphatase; Vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; VHR
Gene Aliases: DUSP3; VHR
UniProt ID: (Human) P51452
Entrez Gene ID: (Human) 1845
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
cytoskeletal protein binding
protein tyrosine/serine/threonine phosphatase activity
hydrolase activity
phosphatase activity
protein kinase binding
receptor signaling protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
MAP kinase phosphatase activity
protein tyrosine kinase binding
negative regulation of signal transduction
dephosphorylation
negative regulation of cell migration
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of MAPK cascade
positive regulation of mitotic cell cycle
negative regulation of JNK cascade
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
negative regulation of chemotaxis
regulation of focal adhesion assembly
negative regulation of ERK1 and ERK2 cascade
cellular response to epidermal growth factor stimulus
positive regulation of focal adhesion disassembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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