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Invitrogen
NALP1 Polyclonal Antibody
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Product Details
PA5-111579
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human NALP1. Recombinant protein control fragment (Product #RP-107337).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CVWDQFLGEI NPQHSWMVAG PLLDIKAEPG AVEAVHLPHF VALQGGHVDT SLFQMAHFKE EGMLLEKPAR VELHHIVLEN PSFSPLGVLL KMIHNALRFI PVTSVVLLYH RVHPEEVTFH LYLIPSDCSI RK
Highest antigen sequence indentity to the following orthologs: Mouse - 64%, Rat - 66%.
Target Information
NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apaf-1/Ced-4 family apoptosis regulator; CARD7; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; contains NACHT, LRR and PYD domains; Death effector filament-forming ced-4-like apoptosis protein; DKFZp586O1822; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; unnamed protein product
Gene Aliases: AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; JRRP; KIAA0926; MSPC; NAC; NALP1; NLRP1; PP1044; SLEV1; VAMAS1
UniProt ID: (Human) Q9C000
Entrez Gene ID: (Human) 22861
nucleotide binding
double-stranded DNA binding
double-stranded RNA binding
endopeptidase activity
protein binding
ATP binding
peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
hydrolase activity
ATPase activity
enzyme binding
protein domain specific binding
signaling adaptor activity
pattern recognition receptor activity
cysteine-type endopeptidase activator activity
molecular condensate scaffold activity
activation of innate immune response
pattern recognition receptor signaling pathway
immune system process
proteolysis
apoptotic process
inflammatory response
signal transduction
programmed cell death
response to muramyl dipeptide
positive regulation of interleukin-1 beta production
defense response to bacterium
regulation of apoptotic process
innate immune response
regulation of inflammatory response
positive regulation of inflammatory response
protein homooligomerization
neuron apoptotic process
protein maturation
defense response to virus
pyroptosis
cellular response to UV-B
intrinsic apoptotic signaling pathway
self proteolysis
antiviral innate immune response
canonical inflammasome complex assembly
positive regulation of pyroptotic inflammatory response
pyroptotic cell death
NLRP1 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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