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Invitrogen
SETD8 Polyclonal Antibody
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Product Details
PA5-111583
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human SETD8. Recombinant protein control fragment (Product #RP-107338).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KDARKGPLVP FPNQKSEAAE PPKTPPSSCD STNAAIAKQA LKKPIKGKQA PRKKAQGKTQ QNRKLTDFYP VRRSSRKSKA ELQSEERKRI DELIESGK
Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 88%.
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H4-K20-HMTase; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; H4-K20-specific histone methyltransferase; Histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine (K)-specific methyltransferase 5A; Lysine N-methyltransferase 5A; Lysine-specific methylase 5A; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; nucleosomal histone H4-K20 methyltransferase; H4-K20-HMTase; PR-Set7; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8; unnamed protein product
Gene Aliases: KMT5A; PR-Set7; PR/SET07; PRSET7; SET07; SET8; SETD8
UniProt ID: (Human) Q9NQR1
Entrez Gene ID: (Human) 387893
transcription corepressor activity
protein binding
methyltransferase activity
lysine N-methyltransferase activity
protein-lysine N-methyltransferase activity
transferase activity
histone methyltransferase activity
histone methyltransferase activity (H4-K20 specific)
histone H4 methyltransferase activity
histone H4K20 monomethyltransferase activity
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
mitotic chromosome condensation
peptidyl-lysine monomethylation
replication fork processing
methylation
regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of transcription, DNA-templated
cell division
protein localization to chromatin
regulation of signal transduction by p53 class mediator
negative regulation of double-strand break repair via homologous recombination
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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