Search
Invitrogen
SPHK2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-111601
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human SPHK2. Recombinant protein control fragment (Product #RP-107433).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LTCLLRGLPL PGDGEITPDL LPRPPRLLLL VNPFGGRGLA WQWCKNHVLP MISEAGLSFN LIQTERQNHA
Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 86%.
Target Information
SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK2 is an important signaling molecule with intra- and extracellular functions and has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide raange of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: lipid kinase; SK 2; Sphingosine kinase 2; SPHK2; unnamed protein product
Gene Aliases: SK 2; SK-2; SK2; SPHK2; SPK 2; SPK-2
UniProt ID: (Human) Q9NRA0
Entrez Gene ID: (Human) 56848
blood vessel development
positive regulation of cytokine production involved in immune response
sphingosine-1-phosphate signaling pathway
lipid metabolic process
sphinganine-1-phosphate biosynthetic process
sphingosine metabolic process
brain development
female pregnancy
cell proliferation
positive regulation of cell proliferation
sphingolipid biosynthetic process
negative regulation of cell growth
positive regulation of interleukin-13 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of mast cell activation involved in immune response
regulation of cellular amide metabolic process
intracellular signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of mast cell degranulation
positive regulation of gene expression, epigenetic
sphingosine biosynthetic process
regulation of lipid biosynthetic process
regulation of transport
regulation of reactive oxygen species biosynthetic process
cellular response to phorbol 13-acetate 12-myristate
regulation of cytochrome-c oxidase activity
positive regulation of ceramide biosynthetic process
regulation of ATP biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support