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Invitrogen
HEC1 Polyclonal Antibody
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Product Details
PA5-111613
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human HEC1. Recombinant protein control fragment (Product #RP-105391).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CYESFMSGAD SFDEMNAELQ SKLKDLFNVD AFKLESLEAK NRALNEQIAR LEQEREKEPN RLESLRKLKA SLQGDVQKYQ
Highest antigen sequence indentity to the following orthologs: Rat - 76%, Mouse - 78%.
Target Information
Hec1 is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HEC-1; HEC2; HEC4; Highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; kinetochore associated 2; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; Retinoblastoma-associated protein HEC
Gene Aliases: HEC; HEC1; HsHec1; hsNDC80; KNTC2; NDC80; TID3
UniProt ID: (Human) O14777
Entrez Gene ID: (Human) 10403
mitotic sister chromatid segregation
establishment of mitotic spindle orientation
mitotic spindle organization
chromosome segregation
sister chromatid cohesion
mitotic nuclear division
attachment of spindle microtubules to kinetochore
cell division
attachment of mitotic spindle microtubules to kinetochore
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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