Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Cell Analysis
    • Antibodies
    • Mass Spectrometry
    • Cell Culture
    • Laboratory Instruments
    • Clinical and Diagnostics
    • Chromatography
    • Laboratory Equipment
    • Laboratory Supplies
    • Molecular Biology and Nucleic Acid Analysis
    • Sequence-Specific Nucleic Acid Products
    • See all product categories
  • Applications
    • Cell Culture and Transfection
    • Flow Cytometry
    • Cancer Research
    • Chromatography
    • Sequencing
    • PCR
    • Lab Solutions
    • Allergy Diagnostics
    • See all applications and techniques
  • Services
    • Cell Biology Services
    • Custom Services
    • Training Services
    • Lab Informatics Services
    • Financial and Leasing Services
    • Partnering and Licensing Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Food Safety Inspection Services
    • See all services
  • Help and Support
    • How to Order
    • Promotions and Online Offers
    • Contact Us
    • Change Location
    • Create a New Account
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Biotech
    • Biopharma
    • CDMO
    • Lab Diagnostics
    • Industrial and Applied Sciences
  • Special Offers
  • Contact Us
  • Quick Order
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Contact Us
          • Quick Order
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Custom Products & Projects
          • Primary Antibodies ›
          • CRK Antibodies

          Invitrogen

          Crk Polyclonal Antibody

          View all (24) CRK antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support

          Cite Crk Polyclonal Antibody

          Additional Information:
          {{banner.description}}
          {{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
          • Antibody Testing Data (1)
          Crk Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Crk Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          Crk Antibody (PA5-111630) in ICC/IF

          Immunofluorecent analysis of Crk in human cell line A549 using Crk Polyclonal Antibody (Product # PA5-111630). Staining shows localization to plasma membrane. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          View Product

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          Crk Antibody in Immunocytochemistry (ICC/IF)
          Crk Polyclonal Antibody

          Product Details

          PA5-111630

          Applications
          Tested Dilution
          Publications

          Immunocytochemistry (ICC/IF)

          0.25-2 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant Protein corresonding to Human Crk. Recombinant protein control fragment (Product #RP-107618).
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.2 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 40% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2857040

          Product Specific Information

          Immunogen sequence: DTTTLIEPVS RSRQGSGVIL RQEEAEYVRA LFDFNGNDEE DLPF

          Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 100%.

          Target Information

          The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: Adapter molecule crk; CSAID-binding protein; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; encoded by transcript variant 4; p38 MAP kinase; encoded by transcript variant 5; p38 MAP kinase; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK14; MAX-interacting protein 2; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; Proto-oncogene c-Crk; SAPK2a; SAPK2a; CSAIDS binding protein 1; Stress-activated protein kinase 2a; unnamed protein product; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_1; v-crk sarcoma virus CT10 oncogene homolog (avian) isoform CRK_2; v-crk sarcoma virus CT10 oncogene-like protein

          View more View less

          Gene Aliases: CRK; CRKII; CSBP; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; MXI2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A

          View more View less

          UniProt ID: (Human) P46108, (Human) Q16539

          View more View less

          Entrez Gene ID: (Human) 1398, (Human) 1432

          View more View less

          Function(s)
          phosphotyrosine binding receptor binding insulin-like growth factor receptor binding protein binding cytoskeletal protein binding SH3 domain binding enzyme binding kinase binding protein domain specific binding receptor signaling complex scaffold activity protein binding, bridging receptor tyrosine kinase binding ubiquitin protein ligase binding signaling adaptor activity SH2 domain binding protein phosphorylated amino acid binding ephrin receptor binding scaffold protein binding protein tyrosine kinase binding nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity ATP binding kinase activity transferase activity protein phosphatase binding mitogen-activated protein kinase p38 binding NFAT protein binding protein serine kinase activity
          Process(es)
          DNA damage checkpoint MAPK cascade cell morphogenesis cartilage condensation angiogenesis osteoblast differentiation placenta development response to dietary excess chondrocyte differentiation negative regulation of inflammatory response to antigenic stimulus glucose metabolic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process chemotaxis cellular response to DNA damage stimulus signal transduction cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway skeletal muscle tissue development positive regulation of gene expression positive regulation of myotube differentiation fatty acid oxidation platelet activation regulation of ossification osteoclast differentiation stress-activated protein kinase signaling cascade positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide response to lipopolysaccharide positive regulation of interleukin-12 production response to insulin tumor necrosis factor-mediated signaling pathway negative regulation of hippo signaling intracellular signal transduction cellular response to vascular endothelial growth factor stimulus response to muscle stretch p38MAPK cascade positive regulation of protein import into nucleus signal transduction in response to DNA damage positive regulation of blood vessel endothelial cell migration positive regulation of erythrocyte differentiation positive regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter glucose import positive regulation of glucose import vascular endothelial growth factor receptor signaling pathway stem cell differentiation striated muscle cell differentiation positive regulation of muscle cell differentiation stress-activated MAPK cascade protein maturation positive regulation of cardiac muscle cell proliferation bone development pyroptosis 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to tumor necrosis factor cellular response to ionizing radiation cellular response to UV-B negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation cellular senescence stress-induced premature senescence cellular response to virus regulation of synaptic membrane adhesion regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion NLRP1 inflammasome complex assembly positive regulation of reactive oxygen species metabolic process neuron migration response to yeast regulation of leukocyte migration lipid metabolic process enzyme linked receptor protein signaling pathway cell proliferation regulation of cell shape regulation of signal transduction positive regulation of smooth muscle cell migration dendrite development cell migration hippocampus development cerebral cortex development establishment of cell polarity actin cytoskeleton organization positive regulation of cell growth regulation of actin cytoskeleton organization regulation of cell adhesion mediated by integrin regulation of Rac protein signal transduction positive regulation of Rac protein signal transduction helper T cell diapedesis response to hepatocyte growth factor reelin-mediated signaling pathway response to hydrogen peroxide regulation of GTPase activity negative regulation of natural killer cell mediated cytotoxicity positive regulation of JNK cascade ephrin receptor signaling pathway regulation of dendrite development cell chemotaxis regulation of wound healing negative regulation of wound healing response to cholecystokinin cellular response to transforming growth factor beta stimulus cellular response to nitric oxide protein localization to membrane postsynaptic specialization assembly cerebellar neuron development positive regulation of substrate adhesion-dependent cell spreading response to peptide regulation of intracellular signal transduction positive regulation of skeletal muscle acetylcholine-gated channel clustering cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus cellular response to endothelin regulation of cell motility negative regulation of cell motility regulation of T cell migration
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          • Social Media
          • Contact Us
          • Report a Site Issue
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Policy
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          Argentina flag icon
          Argentina

          Your items have has been added!


          Host server : magellan-search-green-7d94cb4b65-6wvps:80/100.66.75.98:80.
          git-commit: c9e08c96761173abe34e68f880379696776a4827
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.44.1-2026.02.97.1.0