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Invitrogen
BLK Polyclonal Antibody
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Product Details
PA5-111649
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human BLK. Recombinant protein control fragment (Product #RP-108553).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YTAMNDRDLQ MLKGEKLQVL KGTGDWWLAR SLVTGREGYV PSNFVARVES LEMERWF
Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 86%.
Target Information
B-lymphoid tyrosine kinase (BLK) is a non-receptor tyrosine kinase that belongs to the Src family of kinases. BLK plays an important role in B-cell activation. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase; MGC10442; p55-Blk; Tyrosine-protein kinase Blk
Gene Aliases: BLK; MODY11
UniProt ID: (Human) P51451
Entrez Gene ID: (Human) 640
cytoskeleton organization
transmembrane receptor protein tyrosine kinase signaling pathway
cell differentiation
positive regulation of insulin secretion
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of apoptotic process
innate immune response
regulation of phagocytosis
B cell receptor signaling pathway
regulation of podosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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