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Invitrogen
DDR2 Polyclonal Antibody
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Product Details
PA5-111656
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human DDR2. Recombinant protein control fragment (Product #RP-107731).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FDRIRNFTTM KVHCNNMFAK GVKIFKEVQC YFRSEASEWE PNAISFPLVL DDVNPSARFV TVPLHHRMAS AIKCQ
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 96%.
Target Information
DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD167 antigen-like family member B; CD167b; CD_antigen: CD167b; cell migration-inducing protein 20; Discoidin domain receptor 2; discoidin domain receptor family, member 2; Discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein; hydroxyaryl-protein kinase; MIG16; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; RP11-572K18.1; Tyrosine-protein kinase TYRO10; unnamed protein product
Gene Aliases: DDR2; MIG20a; NTRKR3; TKT; TYRO10; WRCN
UniProt ID: (Human) Q16832
Entrez Gene ID: (Human) 4921
ossification
endochondral bone growth
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
regulation of extracellular matrix disassembly
positive regulation of fibroblast migration
positive regulation of neuron projection development
peptidyl-tyrosine phosphorylation
collagen fibril organization
regulation of bone mineralization
biomineral tissue development
positive regulation of collagen biosynthetic process
regulation of tissue remodeling
chondrocyte proliferation
response to muscle stretch
collagen-activated tyrosine kinase receptor signaling pathway
negative regulation of apoptotic process
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
protein autophosphorylation
positive regulation of fibroblast proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
cellular response to hypoxia
cellular response to transforming growth factor beta stimulus
positive regulation of extracellular matrix disassembly
positive regulation of wound healing
positive regulation of G1/S transition of mitotic cell cycle
negative regulation of hydrogen peroxide-mediated programmed cell death
cellular response to angiotensin
positive regulation of vascular smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell migration
positive regulation of hepatic stellate cell proliferation
positive regulation of hepatic stellate cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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