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Invitrogen

DDR2 Polyclonal Antibody

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DDR2 Polyclonal Antibody

Product Details

PA5-111656

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human DDR2. Recombinant protein control fragment (Product #RP-107731).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Amount

5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2857066

Product Specific Information

Immunogen sequence: FDRIRNFTTM KVHCNNMFAK GVKIFKEVQC YFRSEASEWE PNAISFPLVL DDVNPSARFV TVPLHHRMAS AIKCQ

Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 96%.

Target Information

DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD167 antigen-like family member B; CD167b; CD_antigen: CD167b; cell migration-inducing protein 20; Discoidin domain receptor 2; discoidin domain receptor family, member 2; Discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein; hydroxyaryl-protein kinase; MIG16; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; RP11-572K18.1; Tyrosine-protein kinase TYRO10; unnamed protein product

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Gene Aliases: DDR2; MIG20a; NTRKR3; TKT; TYRO10; WRCN

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UniProt ID: (Human) Q16832

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Entrez Gene ID: (Human) 4921

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding collagen binding ATP binding kinase activity transferase activity protein tyrosine kinase collagen receptor activity
Process(es)
ossification endochondral bone growth cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of extracellular matrix disassembly positive regulation of fibroblast migration positive regulation of neuron projection development peptidyl-tyrosine phosphorylation collagen fibril organization regulation of bone mineralization biomineral tissue development positive regulation of collagen biosynthetic process regulation of tissue remodeling chondrocyte proliferation response to muscle stretch collagen-activated tyrosine kinase receptor signaling pathway negative regulation of apoptotic process positive regulation of osteoblast differentiation positive regulation of protein kinase activity protein autophosphorylation positive regulation of fibroblast proliferation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade cellular response to hypoxia cellular response to transforming growth factor beta stimulus positive regulation of extracellular matrix disassembly positive regulation of wound healing positive regulation of G1/S transition of mitotic cell cycle negative regulation of hydrogen peroxide-mediated programmed cell death cellular response to angiotensin positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of hepatic stellate cell proliferation positive regulation of hepatic stellate cell activation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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