Search
Invitrogen
ITPKB Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-111704
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ITPKB. Recombinant protein control fragment (Product #RP-105573).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GGSPTLGLLG GSPSAQPGTG NVEAGIPSGR MLEPLPCWDA AKDLKEPQCP PGDRVGVQPG NSRVWQGTME KAGLAWTRGT GVQSEGTWES QR
Highest antigen sequence indentity to the following orthologs: Mouse - 61%, Rat - 59%.
Target Information
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is is thought to regulate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is expressed in rat brain and testis. IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Inositol 1,4,5-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; insP 3-kinase B; IP3 3-kinase B; IP3K B; proliferation-inducing protein 37; unnamed protein product
Gene Aliases: IP3-3KB; IP3K; IP3K-B; IP3KB; ITPKB; PIG37
UniProt ID: (Human) P27987
Entrez Gene ID: (Human) 3707
MAPK cascade
myeloid cell homeostasis
signal transduction
cell surface receptor signaling pathway
T cell differentiation
inositol trisphosphate metabolic process
inositol phosphate biosynthetic process
negative regulation of neutrophil apoptotic process
common myeloid progenitor cell proliferation
positive thymic T cell selection
thymic T cell selection
negative regulation of myeloid cell differentiation
positive regulation of Ras protein signal transduction
positive regulation of alpha-beta T cell differentiation
phosphatidylinositol phosphorylation
cellular response to calcium ion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support