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Invitrogen
LRP8 Polyclonal Antibody
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Product Details
PA5-111706
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human LRP8. Recombinant protein control fragment (Product #RP-108261).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HIGRTAQIGH VYPAAISSFD RPLWAEPCLG ETREPEDPAP ALKELFVLPG EPRSQLHQLP KNPLSELPVV KSKRVALSLE DDGLP
Highest antigen sequence indentity to the following orthologs: Rat - 26%, Mouse - 94%.
Target Information
Apolipoprotein E receptor 2 (ApoER2) is an NMDA associated protein found in neurons. It participates in important functions from guiding neurons in the embryonic brain to regulating synaptic signaling. It is also involved in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ApoE receptor 2; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Low-density lipoprotein receptor-related protein 8; LRP-8
Gene Aliases: APOER2; HSZ75190; LRP-8; LRP8; MCI1
UniProt ID: (Human) Q14114
Entrez Gene ID: (Human) 7804
negative regulation of transcription from RNA polymerase II promoter
retinoid metabolic process
proteolysis
lipid metabolic process
endocytosis
receptor-mediated endocytosis
signal transduction
cytokine-mediated signaling pathway
ammon gyrus development
cerebral cortex development
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
response to drug
positive regulation of peptidyl-tyrosine phosphorylation
modulation of synaptic transmission
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
cellular response to growth factor stimulus
cellular response to cholesterol
positive regulation of dendrite development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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