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Invitrogen
EAAC1 Polyclonal Antibody
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Product Details
PA5-140233
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC1A1. Recombinant protein control fragment (Product #RP-109016).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: FGTGIVEKLS KKELEQMDVS SEVNIVNPFA LESTILDNED SDTKKSYVNG GFAVDKSDTI SFTQTSQ
Highest antigen sequence indentity to the following orthologs: Mouse - 97%, Rat - 96%.
Target Information
L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: excitatory amino acid carrier 1; Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 member 1; unnamed protein product
Gene Aliases: DCBXA; EAAC1; EAAT3; HEAAC1; SCZD18; SLC1A1
UniProt ID: (Human) P43005
Entrez Gene ID: (Human) 6505
anion channel activity
L-glutamate transmembrane transporter activity
high-affinity glutamate transmembrane transporter activity
protein binding
chloride transmembrane transporter activity
L-aspartate transmembrane transporter activity
symporter activity
glutamate:sodium symporter activity
cysteine transmembrane transporter activity
identical protein binding
metal ion binding
D-aspartate transmembrane transporter activity
behavioral fear response
response to amphetamine
regulation of heart rate
glutathione metabolic process
glutathione biosynthetic process
superoxide metabolic process
ion transport
neurotransmitter transport
amino acid transport
cellular zinc ion homeostasis
dopamine receptor signaling pathway
glutamate receptor signaling pathway
chemical synaptic transmission
brain development
learning or memory
memory
grooming behavior
locomotory behavior
response to xenobiotic stimulus
positive regulation of heart rate
gene expression
retina layer formation
L-glutamate transport
cytokine-mediated signaling pathway
neurogenesis
adult behavior
cellular response to oxidative stress
maintenance of blood-brain barrier
response to decreased oxygen levels
dopamine metabolic process
cysteine transport
response to morphine
negative regulation of neuron apoptotic process
establishment of protein localization
blood vessel morphogenesis
response to axon injury
synapse organization
neuron apoptotic process
L-glutamate import
righting reflex
retina development in camera-type eye
heart contraction
long-term synaptic potentiation
motor behavior
transepithelial transport
D-aspartate transmembrane transport
L-aspartate transmembrane transport
D-aspartate import
cellular response to ammonium ion
cellular response to mercury ion
cellular response to cocaine
zinc II ion transmembrane transport
response to anesthetic
regulation of protein targeting to membrane
glutamate homeostasis
motor neuron apoptotic process
import into cell
L-glutamate import across plasma membrane
neurotransmitter receptor transport to plasma membrane
postsynaptic modulation of chemical synaptic transmission
L-aspartate import across plasma membrane
transport across blood-brain barrier
chloride transmembrane transport
cysteine transmembrane transport
cellular response to bisphenol A
conditioned place preference
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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