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Invitrogen
SLC4A10 Polyclonal Antibody
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Product Details
PA5-140340
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC4A10. Recombinant protein control fragment (Product #RP-109587).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: FSKGLGGQQK GHTSPCGMKQ RHEKGPPHQQ EREVDLH
Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 95%.
Target Information
Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. NCBE (SLC4A10) is a member of the SLC4 family of bicarbonate transporters, several of which play important roles in intracellular-pH regulation and transepithelial HCO(3)(-) transport. The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B. SLC4A10 encodes a sodium bicarbonate transporter with a brain-restricted expression pattern. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been associated with idiopathic epilepsy and other neurological symptoms. Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NBCN2; NCBE; SLC4A10; Sodium-Driven Chloride Bicarbonate Exchanger; Solute carrier family 4 member 10; solute carrier family 4, sodium bicarbonate cotransporter-like, member 10; solute carrier family 4, sodium bicarbonate transporter, member 10; unnamed protein product
Gene Aliases: NBCN2; NCBE; SLC4A10
UniProt ID: (Human) Q6U841
Entrez Gene ID: (Human) 57282
ion transport
sodium ion transport
anion transport
chloride transport
regulation of pH
visual perception
response to light stimulus
post-embryonic development
bicarbonate transport
pyramidal neuron development
regulation of cellular pH
multicellular organism growth
locomotory exploration behavior
sodium ion transmembrane transport
regulation of short-term neuronal synaptic plasticity
brain morphogenesis
regulation of intracellular pH
transmembrane transport
anion transmembrane transport
hydrogen ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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