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Invitrogen
Claudin 19 Polyclonal Antibody
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Product Details
PA5-144714
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 37-71. Recombinant protein control fragment (Product #RP-109977).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GDAIITAVGL YEGLWMSCAS QSTGQVQCKL YDSLL
Antigen sequence identity: Mouse 100%; Rat 100%
Target Information
The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Claudin-19; unnamed protein product
Gene Aliases: CLDN19; HOMG5
UniProt ID: (Human) Q8N6F1
Entrez Gene ID: (Human) 149461
retinal pigment epithelium development
cell adhesion
visual perception
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
neuronal action potential propagation
actin cytoskeleton organization
negative regulation of cell migration
cell junction assembly
apical junction assembly
renal absorption
bicellular tight junction assembly
tight junction organization
regulation of transepithelial transport
paracellular transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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