Search
Invitrogen
P2X1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-144864
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 187-253. Recombinant protein control fragment (Product #RP-110019).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LFIKNSISFP RFKVNRRNLV EEVNAAHMKT CLFHKTLHPL CPVFQLGYVV QESGQNFSTL AEKGGVV
Antigen sequence identity: Mouse 84%; Rat 82%
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ATP receptor; ligand gated ion channel; P2X purinoceptor 1; P2X receptor, subunit 1; P2X1; P2X1 receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 1; purinergic receptor P2X1; unnamed protein product
Gene Aliases: P2RX1; P2X1
UniProt ID: (Human) P51575
Entrez Gene ID: (Human) 5023
nucleotide binding
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ion channel activity
cation channel activity
protein binding
ATP binding
channel activity
identical protein binding
suramin binding
macromolecular complex binding
ligand-gated calcium channel activity
serotonin secretion by platelet
regulation of vascular smooth muscle contraction
ion transport
apoptotic process
regulation of smooth muscle contraction
signal transduction
insemination
regulation of blood pressure
neuronal action potential
regulation of vasoconstriction
calcium-mediated signaling
platelet activation
response to ATP
ion transmembrane transport
synaptic transmission, glutamatergic
purinergic nucleotide receptor signaling pathway
positive regulation of ion transport
ceramide biosynthetic process
establishment of localization in cell
regulation of calcium ion transport
excitatory postsynaptic potential
calcium ion transmembrane transport
cation transmembrane transport
regulation of presynaptic cytosolic calcium ion concentration
positive regulation of calcium ion import across plasma membrane
regulation of synaptic vesicle exocytosis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support