Search
Invitrogen
Kir3.1 (KCNJ3) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-144915
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 3-66. Recombinant protein control fragment (Product #RP-110165).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ALRRKFGDDY QVVTTSSSGS GLQPQGPGQD PQQQLVPKKK RQRFVDKNGR CNVQHGNLGS ETSR
Antigen sequence identity: Mouse 98%; Rat 98%
Target Information
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: G protein-activated inward rectifier potassium channel 1; GIRK-1; HGIRK1; hGIRK1c; hGIRK1d; hGIRK1e; Inward rectifier K(+) channel Kir3.1; inward rectifier K+ channel KIR3.1; Potassium channel, inwardly rectifying subfamily J member 3; potassium voltage-gated channel subfamily J member 3; unnamed protein product
Gene Aliases: GIRK1; KCNJ3; KGA; KIR3.1
UniProt ID: (Human) P48549
Entrez Gene ID: (Human) 3760
inward rectifier potassium channel activity
protein binding
phosphatidylinositol-4,5-bisphosphate binding
G-protein activated inward rectifier potassium channel activity
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
ion transport
potassium ion transport
ion transmembrane transport
regulation of ion transmembrane transport
response to electrical stimulus
potassium ion transmembrane transport
regulation of heart rate by cardiac conduction
membrane repolarization during atrial cardiac muscle cell action potential
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of presynaptic membrane potential
ventricular cardiac muscle cell membrane repolarization
potassium ion import across plasma membrane
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support