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Invitrogen
CCDC88C Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-144920
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NGSVGKGPGD LKPKRGSPHR GSLDRTDAST DLAMRSWPSE LGSRTCSTSA TTTAPSNSTP IARHPGRTKG YNSDDNLCEP SLE
Antigen sequence identity: Mouse 78%; Rat 76%
Target Information
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the disheveled protein and is a negative regulator of the Wnt signaling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the disheveled protein. Disheveled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coiled-coil domain containing 88C; Dvl-associating protein with a high frequency of leucine residues; hook-related protein 2; spinocerebellar ataxia 40; unnamed protein product
Gene Aliases: DAPLE; HKRP2; HYC1; KIAA1509; SCA40
UniProt ID: (Human) Q9P219
Entrez Gene ID: (Human) 440193
apical constriction
signal transduction
small GTPase mediated signal transduction
cytoskeleton-dependent intracellular transport
cytoplasmic microtubule organization
protein destabilization
non-canonical Wnt signaling pathway
positive regulation of JNK cascade
negative regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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