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Invitrogen
ID1 Polyclonal Antibody
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Product Details
PA5-144964
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment of Human ID1 (Product #RP-106336).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DYIRDLQLEL NSESEVGTPG GRGLPVRAPL STLNGEISAL TAEAACVPAD DRILCR
Antigen sequence identity: Mouse 96%; Rat 95%
Target Information
ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. It has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHb24; Class B basic helix-loop-helix protein 24; dJ857M17.1.2; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); DNA-binding protein inhibitor ID-1; Inhibitor of differentiation 1; Inhibitor of DNA binding 1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Gene Aliases: BHLHB24; ID; ID1
UniProt ID: (Human) P41134
Entrez Gene ID: (Human) 3397
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
endothelial cell morphogenesis
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
brain development
heart development
circadian rhythm
negative regulation of transcription by transcription factor localization
positive regulation of gene expression
neuron differentiation
BMP signaling pathway
protein destabilization
positive regulation of actin filament bundle assembly
collagen metabolic process
cell-abiotic substrate adhesion
negative regulation of apoptotic process
regulation of MAPK cascade
negative regulation of sequence-specific DNA binding transcription factor activity
blood vessel endothelial cell migration
negative regulation of endothelial cell differentiation
negative regulation of osteoblast differentiation
regulation of angiogenesis
negative regulation of transcription, DNA-templated
response to antibiotic
blood vessel morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of dendrite morphogenesis
lung morphogenesis
lung vasculature development
cellular response to epidermal growth factor stimulus
negative regulation of protein homodimerization activity
cellular response to peptide
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
cellular response to dopamine
cellular response to nerve growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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