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Invitrogen
KCNQ1 Polyclonal Antibody
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Product Details
PA5-144998
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 545-604. Recombinant protein control fragment (Product #RP-110230).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YSQGHLNLMV RIKELQRRLD QSIGKPSLFI SVSEKSKDRG SNTIGARLNR VEDKVTQLDQ
Antigen sequence identity: Mouse 97%; Rat 97%
Target Information
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; slow delayed rectifier channel subunit; tKvLQT1; unnamed protein product; Voltage-gated potassium channel subunit Kv7.1
Gene Aliases: ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; KCNQ1; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS
UniProt ID: (Human) P51787
Entrez Gene ID: (Human) 3784
ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
protein binding
calmodulin binding
phosphatidylinositol-4,5-bisphosphate binding
protein phosphatase 1 binding
outward rectifier potassium channel activity
ubiquitin protein ligase binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
ion channel binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
scaffold protein binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
action potential
gastric acid secretion
gastrin-induced gastric acid secretion
regulation of heart rate
system process
glucose metabolic process
ion transport
potassium ion transport
sodium ion transport
heart development
sensory perception of sound
rhythmic behavior
regulation of heart contraction
regulation of blood pressure
positive regulation of heart rate
iodide transport
digestive system process
erythrocyte differentiation
cellular chloride ion homeostasis
response to insulin
ion transmembrane transport
social behavior
corticosterone secretion
regulation of membrane potential
inner ear morphogenesis
inner ear development
intestinal absorption
detection of mechanical stimulus involved in sensory perception of sound
regulation of transport
chloride ion homeostasis
potassium ion homeostasis
transmembrane transport
cardiac muscle contraction
auditory receptor cell development
regulation of membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane repolarization
positive regulation of cardiac muscle contraction
regulation of gastric acid secretion
cardiac conduction
stomach development
renal absorption
renal sodium ion absorption
cellular response to cAMP
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
cardiac muscle cell contraction
ventricular cardiac muscle cell action potential
membrane repolarization
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
atrial cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
cochlea development
potassium ion export across plasma membrane
membrane repolarization during atrial cardiac muscle cell action potential
membrane repolarization during ventricular cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transport
negative regulation of delayed rectifier potassium channel activity
negative regulation of voltage-gated potassium channel activity
non-motile cilium assembly
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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