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Invitrogen
PHF17 Polyclonal Antibody
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Product Details
PA5-145034
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 631-732. Recombinant protein control fragment (Product #RP-109729).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LGLEKTFAEA RLISAQQKNG VVMPDHGKRR DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA ATSPGVGQSA PGTRKEIVPK CNGSLIKVNY NQ
Antigen sequence identity: Mouse 89%; Rat 89%
Target Information
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gene for apoptosis and differentiation in epithelia; Jade family PHD finger protein 1; PHD finger protein 17; PHD protein Jade-1; Protein Jade-1
Gene Aliases: JADE1; KIAA1807; PHF17
UniProt ID: (Human) Q6IE81
Entrez Gene ID: (Human) 79960
transcription, DNA-templated
apoptotic process
response to stress
negative regulation of cell growth
histone H3 acetylation
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K12 acetylation
histone H4-K16 acetylation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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