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Invitrogen
GRIK1 Polyclonal Antibody
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Product Details
PA5-145060
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 400-449. Recombinant protein control fragment (Product #RP-109925).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TEKAAGEVSK HLYKVWKKIG IWNSNSGLNM TDSNKDKSSN ITDSLANRTL
Antigen sequence identity: Mouse 90%; Rat 90%
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAA3; Excitatory amino acid receptor 3; GluK1; GluK1(del_e2); GluR-5; glutamate receptor; Glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; unnamed protein product
Gene Aliases: EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5; GRIK1
UniProt ID: (Human) P39086
Entrez Gene ID: (Human) 2897
ionotropic glutamate receptor activity
ion channel activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
glutamate-gated calcium ion channel activity
signaling receptor activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
glutamate receptor signaling pathway
chemical synaptic transmission
nervous system development
central nervous system development
calcium-mediated signaling
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
modulation of synaptic transmission
regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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