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Invitrogen
TIP60 Polyclonal Antibody
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Product Details
PA5-145070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 417-510. Recombinant protein control fragment (Product #RP-109873).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YWSQTILEIL MGLKSESGER PQITINEISE ITSIKKEDVI STLQYLNLIN YYKGQYILTL SEDIVDGHER AMLKRLLRID SKCLHFTPKD WSKR
Antigen sequence identity: Mouse 100%; Rat 100%
Target Information
TIP60 is a transcription factor, originally isolated as an HIV-1 TAT-interactive protein, known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyl transferases (HATs). TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60 kDa Tat-interactive protein; cPLA(2)-interacting protein; cPLA2 interacting protein; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 Tat interactive protein, 60kDa; K(lysine) acetyltransferase 5; K-acetyltransferase 5; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; Protein acetyltransferase KAT5; Protein crotonyltransferase KAT5; Protein lactyltransferase KAT5; Tat interacting protein, 60kDa; Tip60; TIP60(HTATIP)
Gene Aliases: cPLA2; ESA1; HTATIP; HTATIP1; KAT5; PLIP; TIP; TIP60; ZC2HC5
UniProt ID: (Human) Q92993
Entrez Gene ID: (Human) 10524
negative regulation of transcription from RNA polymerase II promoter
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
double-strand break repair
double-strand break repair via nonhomologous end joining
transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
response to ionizing radiation
viral process
histone acetylation
androgen receptor signaling pathway
negative regulation of interleukin-2 production
regulation of growth
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to estradiol stimulus
regulation of signal transduction by p53 class mediator
positive regulation of protein acetylation
beta-catenin-TCF complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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