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Invitrogen
BRD2 Polyclonal Antibody
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Product Details
PA5-145079
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 555-602. Recombinant protein control fragment (Product #RP-109932).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KKKRKAEKHR GRAGADEDDK GPRAPRPPQP KKSKKASGSG GGSAALGP
Antigen sequence identity: Mouse 77%; Rat 75%
Target Information
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21. 3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRD2 intronic transcript 1; Bromodomain-containing protein 2; DADB-17J1.3; DKFZp686N0336; female sterile homeotic-related gene 1; FLJ31942; FSH; KIAA9001; O27.1.1; putative; really interesting new gene 3 protein; RING3 protein
Gene Aliases: BRD2; BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; KIAA9001; NAT; O27.1.1; RING3; RNF3
UniProt ID: (Human) P25440
Entrez Gene ID: (Human) 6046
neural tube closure
chromatin organization
nucleosome assembly
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade
spermatogenesis
regulation of gene expression
protein localization to chromatin
T-helper 17 cell lineage commitment
chromatin looping
positive regulation of T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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