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Invitrogen
MICAL3 Polyclonal Antibody
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Product Details
PA5-51431
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MICAL3. Recombinant protein control fragment (Product #RP-91479).
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PVQSQSDTKD RLGSPLAVDE ALRRSDLVEE FWMKSAEIRR SLGLTPVDRS KGPEPSFPTP AFRPVSLKSY SVEKSPQDEG LHLLKPLSIP KRLGLPKPEG EPLSLPTPRS PSDRELRSAQ EERRELSSSS GLGLHGSSSN MKTL
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 80%.
Target Information
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [F-actin]-methionine sulfoxide oxidase MICAL3; [F-actin]-monooxygenase MICAL3; Em:AC016026.2; flavoprotein oxidoreductase MICAL3; MICAL-3; Molecule interacting with CasL protein 3; protein MICAL-3; protein-methionine sulfoxide oxidase MICAL3; unnamed protein product
Gene Aliases: KIAA0819; KIAA1364; MICAL-3; MICAL3
UniProt ID: (Human) Q7RTP6
Entrez Gene ID: (Human) 57553
actin binding
monooxygenase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
metal ion binding
binding, bridging
FAD binding
F-actin monooxygenase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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