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Invitrogen
FCN1 Polyclonal Antibody
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FIGURE: 1 / 7
FCN1 Antibody (PA5-51437) in IHC (P)
Immunohistochemistry analysis of FCN1 in human bone marrow, gastrointestinal, lymphoid tissues and pancreas. Samples were incubated with FCN1 polyclonal antibody (Product # PA5-51437). Shows similar protein distribution across tissues to independent FCN1 antibody (Product # PA5-51552) (B).
Product Details
PA5-51437
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human M-Ficolin. Recombinant protein control fragment (Product #RP-93672).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LAVLLVLFLH IKNLPAQAAD TCPEVKVVGL EGSDKLTILR GCPGLPGAPG PKGEAGVIGE RGERGLPGAP GKAGPVGPKG DRGEKGMRGE KGDAGQSQSC ATGPRNCKD
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 75%.
Target Information
M-Ficolin (Ficolin-1) is a non-serum protein that is expressed in leukocytes and lung. M-Ficolin precipitates with mannose-binding lectin (MBL)-associated serine proteases (MASP)-1 and MASP-2, indicating that M-Ficolin forms complexes with MASP-1 and MASP-2, recognizes certain types of bacteria and subsequently activates the lectin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagen/fibrinogen domain-containing protein 1; ficolin (collagen/fibrinogen domain-containing) 1; Ficolin-1; Ficolin-A; Ficolin-alpha; M-ficolin; unnamed protein product
Gene Aliases: FCN1; FCNM
UniProt ID: (Human) O00602
Entrez Gene ID: (Human) 2219
complement activation, lectin pathway
activation of membrane attack complex
immune system process
cell surface pattern recognition receptor signaling pathway
proteolysis
complement activation
G-protein coupled receptor signaling pathway
opsonization
zymogen activation
killing of cells of other organism
positive regulation of interleukin-8 production
protein localization to cell surface
recognition of apoptotic cell
innate immune response
negative regulation of viral entry into host cell
protein maturation
positive regulation of opsonization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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