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Invitrogen
PYGL Polyclonal Antibody
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Product Details
PA5-51492
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PYGL. Recombinant protein control fragment (Product #RP-88883).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MRIDDVAALD KKGYEAKEYY EALPELKLVI DQIDNGFFSP KQPDLFKDII NMLFYHDRFK VFADYEAYVK CQDKVSQLYM NPKAWNTMVL KNIAASGKFS SDRTIKEYAQ NIWNVEPSD
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.
Target Information
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: glycogen liver; glycogen phosphorylase (EC 2.4.1.1); glycogen phosphorylase type IV; Glycogen phosphorylase, liver form; GPLL; phosphorylase, glycogen, liver; unnamed protein product
Gene Aliases: GSD6; PYGL
UniProt ID: (Human) P06737
Entrez Gene ID: (Human) 5836
nucleotide binding
purine nucleobase binding
catalytic activity
phosphorylase activity
protein binding
ATP binding
glucose binding
glycogen phosphorylase activity
AMP binding
transferase activity
transferase activity, transferring glycosyl groups
vitamin binding
pyridoxal phosphate binding
bile acid binding
identical protein binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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