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Invitrogen
RhoGAP4 Polyclonal Antibody
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Product Details
PA5-51499
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RhoGAP4. Recombinant protein control fragment (Product #RP-91916).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EHNGMRGLIP HKYITLPAGT EKQVVGAGLQ TAGESGSSPE GLLASELVHR PEPCTSPEAM GPSGHRRRCL VPASPEQHVE VDKAVAQNMD SVFKELLGKT SVRQGLGPAS TTSP
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 72%.
Target Information
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase-activating protein p115; KIAA0131; p115; RG RhoGAP4; Rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4; unnamed protein product
Gene Aliases: A130009C12Rik; A530015A20Rik; ARHGAP4; C1; KIAA0131; mKIAA0131; p115; RGC1; RHOGAP4; SrGAP4
UniProt ID: (Human) P98171
Entrez Gene ID: (Human) 393, (Mouse) 171207, (Rat) 246249
cytoskeleton organization
signal transduction
Rho protein signal transduction
nervous system development
negative regulation of fibroblast migration
negative regulation of cell migration
negative regulation of axon extension
regulation of small GTPase mediated signal transduction
regulation of synapse assembly
positive regulation of GTPase activity
regulation of Rho protein signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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