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Invitrogen
RNF139 Polyclonal Antibody
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Product Details
PA5-51534
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RNF139. Recombinant protein control fragment (Product #RP-96771).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PEIKGSRLQE INDVCAICYH EFTTSARITP CNHYFHALCL RKWLYIQDTC PMCHQKVYIE DDIKDNSNVS NNNGFIPPNE TPEEAVREAA AESDRELNED DSTDCDDDVQ RERNGVIQHT GAAAEEF
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a ttranslocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RNF139; MGC31961; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; RING finger protein 139; RING-type E3 ubiquitin transferase RNF139; RNF139; Translocation in renal carcinoma on chromosome 8 protein
Gene Aliases: HRCA1; RCA1; RNF139; TRC8
UniProt ID: (Human) Q8WU17
Entrez Gene ID: (Human) 11236
protein polyubiquitination
negative regulation of cell proliferation
protein ubiquitination
negative regulation of translation
regulation of protein ubiquitination
protein destabilization
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of ER to Golgi vesicle-mediated transport
regulation of protein processing
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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