Search
Invitrogen
Contactin 2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-51571
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Contactin 2. Recombinant protein control fragment (Product #RP-94791).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PASPSANATT MKPPPRRPPG NISWTFSSSS LSIKWDPVVP FRNESAVTGY KMLYQNDLHL TPTLHLTGKN WIEIPVPEDI GHALVQIRTT GPGGDGIPAE VHIVRNGGTS MMVENMAVRP APHPGTVISH SVAMLIL
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 84%.
Target Information
Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Axonal glycoprotein TAG-1; Axonin 1; Axonin-1; axonin-1 cell adhesion molecule; Axonin1; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin-2; Contactin2; DKFZp781D102; MGC157722; TAX-1; Transient axonal glycoprotein 1; unnamed protein product
Gene Aliases: AXT; CNTN2; EPEO5; FAME5; TAG-1; TAG1; TAX; TAX1
UniProt ID: (Human) Q02246
Entrez Gene ID: (Human) 6900
microtubule cytoskeleton organization
neuron migration
adenosine receptor signaling pathway
response to dietary excess
reduction of food intake in response to dietary excess
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
axon guidance
axonal fasciculation
learning
adult walking behavior
positive regulation of protein processing
protein processing
cerebral cortex GABAergic interneuron migration
central nervous system neuron differentiation
central nervous system myelination
regulation of cell morphogenesis
regulation of axon diameter
neuron projection development
receptor internalization
clustering of voltage-gated potassium channels
fat cell differentiation
negative regulation of neuron differentiation
regulation of neuronal synaptic plasticity
regulation of astrocyte differentiation
synapse organization
establishment of localization in cell
positive regulation of adenosine receptor signaling pathway
dendrite self-avoidance
protein localization to juxtaparanode region of axon
establishment of protein localization to juxtaparanode region of axon
presynaptic membrane organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support