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Invitrogen
EGFL6 Polyclonal Antibody
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Product Details
PA5-51642
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EGFL6. Recombinant protein control fragment (Product #RP-94750).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CSFNHGICDW KQDREDDFDW NPADRDNAIG FYMAVPALAG HKKDIGRLKL LLPDLQPQSN FCLLFDYRLA GDKVGKLRVF VKNSNNALAW EKTTSEDEKW KTGKIQLYQG TDATKSIIFE AERGKGKTGE IAVDGVLLVS GLCPD
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.
Target Information
The EGFL6 gene encodes epidermal growth factor-like domain-containing protein 6, a member of the EGF-like repeat superfamily known for its roles in development and angiogenesis. EGFL6 is expressed at higher levels during embryonic development and has notable expression in various malignant tumors, highlighting its potential involvement in cancer progression. This secreted protein is pivotal in promoting tumor angiogenesis, influencing cancer cell migration and proliferation without affecting wound healing, making it a significant factor in tumor growth and metastasis. EGFL6 is also expressed in adipose tissues, and its role in adipose differentiation suggests it might link obesity to endometrial cancer risks. The protein impacts cellular activities such as cell adhesion, migration, and proliferation, contributing fundamentally to tumor dynamics. Consequently, EGFL6 is considered an attractive target for antibody-based therapies, with research evaluating its utility in cancer intervention strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EGF repeat-containing protein 6; EGF-like protein 6; EGF-like-domain, multiple 6; Epidermal growth factor-like protein 6; MAM and EGF domain containing; MAM and EGF domains-containing gene protein
Gene Aliases: EGFL6; MAEG; PP648; UNQ281/PRO320; W80
UniProt ID: (Human) Q8IUX8
Entrez Gene ID: (Human) 25975
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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