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Invitrogen
HUWE1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-51719
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HUWE1. Recombinant protein control fragment (Product #RP-92119).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SGSSTTRLTQ GIGRSQRTLR QLTANTGHTI HVHYPGNRQP NPPLILQRLL GPSAAADILQ LSSSLPLQSR GRARLLVGND DVHIIARSDD ELLDDFFHDQ STATSQAGTL SSIPTALTRW TEECKVLDAE SMHDCVSVVK VSIVNHLE
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 86%.
Target Information
SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARF-binding protein 1; BJ-HCC-24 tumor antigen; DNA binding protein; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT-type E3 ubiquitin transferase HUWE1; homologous to E6AP carboxyl terminus homologous protein 9; KIAA0312; large structure of URE B1; large structure of UREB1; Mcl-1 ubiquitin ligase E3; MULE; RP3-339A18.4; ubiquitin ligase with HECT domain; unnamed protein product; upstream regulatory element-binding protein 1; URE-binding protein 1; UREB1
Gene Aliases: ARF-BP1; HECTH9; HSPC272; Ib772; LASU1; MRXST; MULE; URE-B1; UREB1
UniProt ID: (Human) Q7Z6Z7
Entrez Gene ID: (Human) 10075
protein polyubiquitination
base-excision repair
chromatin remodeling
ubiquitin-dependent protein catabolic process
protein monoubiquitination
Golgi organization
negative regulation of mitochondrial fusion
protein ubiquitination
positive regulation of protein ubiquitination
circadian regulation of gene expression
negative regulation of peroxisome proliferator activated receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
membrane fusion
protein K48-linked ubiquitination
protein branched polyubiquitination
positive regulation of establishment of protein localization to mitochondrion
positive regulation of type 2 mitophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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