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Invitrogen
MED12 Polyclonal Antibody
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Product Details
PA5-51851
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MED12. Recombinant protein control fragment (Product #RP-92261).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RLLLYHTHLR PRPRAYYLEP LPLPPEDEEP PAPTLLEPEK KAPEPPKTDK PGAAPPSTEE RKKKSTKGKK RSQPATKTED YGMGPGRSGP YGVTVPPDLL HHPNPGSITH LNYRQGSIGL YTQNQ
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; HOPA; human opposite paired; KIAA0192; Kohtalo homolog; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; mediator of RNA polymerase II transcription, subunit 12 homolog; OPA-containing protein; putative mediator subunit 12; Thyroid hormone receptor-associated protein complex 230 kDa component; thyroid hormone receptor-associated protein, 230 kDa subunit; TNRC11; Trap230; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); Trinucleotide repeat-containing gene 11 protein; unnamed protein product
Gene Aliases: ARC240; CAGH45; FGS1; HDKR; HOPA; KIAA0192; Kto; MED12; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
UniProt ID: (Human) Q93074
Entrez Gene ID: (Human) 9968
somitogenesis
neural tube closure
regulation of transcription from RNA polymerase II promoter
endoderm development
heart development
oligodendrocyte development
Schwann cell development
protein ubiquitination
spinal cord development
neural tube development
somatic stem cell population maintenance
post-anal tail morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
embryonic neurocranium morphogenesis
Wnt signaling pathway, planar cell polarity pathway
positive regulation of transcription initiation from RNA polymerase II promoter
axis elongation involved in somitogenesis
embryonic brain development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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