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Invitrogen
NPNT Polyclonal Antibody
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Product Details
PA5-51988
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NPNT. Recombinant protein control fragment (Product #RP-101074).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RQCVNTFGSY ICKCHKGFDL MYIGGKYQCH DIDECSLGQY QCSSFARCYN VRGSYKCKCK EGYQGDGLTC VYIPKVMIEP SGPIHVPKGN GTILKGDTGN NNWIPDVGST WWPPKTPYIP PIITNRPTSK PTTRPTPK
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 54%.
Target Information
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nephronectin; Preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like
Gene Aliases: EGFL6L; NPNT; POEM; UNQ295/PRO334
UniProt ID: (Human) Q6UXI9
Entrez Gene ID: (Human) 255743
ureteric bud development
branching involved in ureteric bud morphogenesis
cell-matrix adhesion
positive regulation of alkaline phosphatase activity
positive regulation of cell-substrate adhesion
extracellular matrix organization
positive regulation of transforming growth factor beta receptor signaling pathway
cell-cell adhesion mediated by integrin
establishment of protein localization
positive regulation of osteoblast differentiation
positive regulation of smooth muscle contraction
positive regulation of ERK1 and ERK2 cascade
cellular response to tumor necrosis factor
pilomotor reflex
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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